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Where are Salivary Glands?
The glands are located in and around the mouth and throat. The major
salivary glands are called the parotid, submandibular and sublingual
glands. (See illustration)

They all secrete saliva into the mouth: the parotid through ducts
near the upper teeth, submandibular into the front portion under the
tongue, and the sublingual through multiple ducts in the floor of
the mouth.
In addition to these glands, there are hundreds of tiny glands
called minor salivary glands located in the lips, inner cheek area (buccal
mucosa) and extensively in other linings of the mouth and throat.
Salivary glands produce the saliva used to moisten your mouth,
initiate digestion, and help protect teeth from decay.
What causes abnormal glands?
Abnormalities of the salivary glands which cause clinical symptoms
can be grouped as follows:
1. Obstruction
Obstruction to the flow of saliva most commonly occurs in the
parotid and submandibular glands, usually due to stone formation.
Symptoms typically occur when eating. Saliva production is
initiated, but cannot exit the ductal system, leading to swelling of
the involved gland and significant pain, sometimes with an
infection.
Secondary infection of salivary glands from adjacent lymph nodes
also occurs. These lymph nodes are the glands in the upper neck
which often become tender during a common sore throat Many of these
lymph nodes are actually located on, within, and deep in the
substance of the parotid gland, near the submandibular glands. When
these lymph nodes enlarge through infection, this is noticed by the
patient as a red, painful swelling in the area of the parotid or
submandibular glands. Lymph nodes also enlarge due to tumors and
inflammation.
2. Inflammation
If stones are not totally obstructive, the major glands will swell
during eating and then gradually subside after eating, only to
enlarge again at the next meal. Infection often develops in the
abnormally pooled saliva, leading to more severe pain and swelling
in the glands. If untreated long enough, the glands may become
abscessed.
In some individuals the duct system of the major salivary glands may
be abnormal. These ducts can develop small constrictions which
decrease salivary flow, leading to infection and obstructive
symptoms.
3. Infection
The most common salivary gland infection is mumps, which involves
the parotid glands. While this is most common in children, it can
occur in adults. However if an adult has swelling in the area of the
parotid gland on one side, it is more likely due to an obstruction
or a tumor.
Infections occurring because of ductal obstruction or sluggish flow
of saliva have already been mentioned.
4. Rumors
Primary benign and malignant salivary gland tumors usually show up
as painless enlargements of these glands. Tumors rarely involve more
than one gland and are detected as a growth in the parotid,
submandibular area, on the palate, floor of mouth, cheeks, or lips.
These enlargements should be checked by an otolaryngologist-head and
neck surgeon.
Malignant tumors of the major salivary glands can grow quickly, are
painful, and can cause loss of movement of part or all of the
affected side of the face. These symptoms should be immediately
investigated.
Salivary gland enlargement is also seen in auto-immune diseases,
which cause significant inflammation. Patients often have a dry
mouth or dry eyes. This may occur with other systemic diseases such
as rheumatoid arthritis. Diabetes may cause enlargement of the
salivary glands, especially the parotid glands. Salivary gland
swelling (usually on both sides) is also seen in alcoholics.
How does your doctor make the diagnosis?
The diagnosis of salivary gland disease depends upon a careful
history, a physical examination, and laboratory tests. If an
obstruction of the major salivary glands is suspected, it may be
necessary to anesthetize the opening of the salivary ducts in the
mouth, and to probe, and dilate the duct to help an obstructive
stone pass. Prior to such instrumentation, dental x-rays may show
the location of calcified stones.
If a mass is found in the salivary gland, it is helpful to obtain an
x-ray called a CT scan. CT scans will show whether the mass is an
actual part of a salivary gland, or an associated lymph node.
In many cases a fine needle aspiration biopsy in the doctor's office
is helpful. The accuracy of this test is approximately 80% to 90%.
An open biopsy, where a skin incision is made and a small sample of
the gland removed, is not usually recommended in the office. This is
an incisional biopsy and because of the possibility of injury to
underlying nerves within the parotid gland may need to be done in
the operating room.
Treatment of Salivary Gland Disease
Treatment of salivary diseases is broadly classified into two
categories: medical and surgical. Selection of treatment depends
upon the nature of the problem. If it is due to systemic diseases
(diseases that involve the whole body, not one isolated area), then
the underlying problem process must be treated. This may require
consultation with other specialists. If the disease process relates
to salivary gland obstruction and subsequent infection, antibiotics
are used. Sometimes instrumentation of the ducts will be needed.
If a mass has developed within the salivary gland, removal of the
mass may be required. Most masses in the parotid gland area are
benign. When surgery is necessary, great care must be taken to avoid
damage to the facial nerve which lies within this gland. When
malignant masses are present in the parotid gland, it may be
possible to surgically remove these masses and preserve most of the
facial nerve. Radiation treatment will often be recommended after
surgery. This is typically administered four to six weeks after the
surgical procedure to allow adequate healing before irradiation.
The same general principles apply to masses in the submandibular
area or in the minor salivary glands within the mouth and upper
throat. Benign diseases are best treated by surgery alone, whereas
malignant diseases may require surgery and postoperative
irradiation. If the mass in the vicinity of a salivary gland is a
lymph node which has become enlarged due to cancer from another
site, then obviously a different treatment plan will be necessary.
Such treatment can be very effectively directed by an
otolaryngologist-head and neck surgeon.
In summary, salivary gland diseases are due to many different
causes. These diseases are treated both medically and surgically.
Such treatment is readily managed by an otolaryngologist-head and
neck surgeon with experience in this area.